Since My 600-lb Life premiered in 2012, the show has featured stars who have tragically passed away during and after their mission to lose weight. My 600-lb Life is a series featuring tragic moments set up to follow and document the lives of multiple in their quest to lose hundreds of pounds due to health reasons. These individuals weighing over 600 lbs turn to Dr. Younan Nowzardan (Dr. Now) to help them achieve their weight loss goals through a healthy nutrition plan and strict low-calorie diet, which prepares them for bariatric surgery.

During My 600-Lb Life, Dr. Now has helped many patients attain their goals and to live healthy and productive lives. However, some of these individuals found it more difficult than others to lose weight. In fact, some found it so challenging they were never able to achieve their weight loss goals. Here's a look at My 600-Lb Life cast members who tragically died, what happened to them on and after the show, and what ultimately caused their deaths.

13 Henry Foots (My 600-Lb Life Season 1)

Henry Foots was the second person to appear in the series when he approached Dr. Now to lose weight for his high school reunion. The Texas native quickly became a fan-favorite due to his story and determination to lose weight. Henry would become one of Dr. Now's most successful patients as he dropped from about 750 pounds to almost 275 pounds.

While Henry got his life back after the weight loss, he was back in the news in 2012 after tragically killing a woman on the street due to losing control of a shuttle bus he was driving. Although he survived the accident, Henry died a year later, in May 2013. His family didn't make his cause of death public.

12 Ashley Randall (My 600-Lb Life Season 1)

Ashley Randall appeared on My 600-Lb Life season 1. She was initially a success story on the show, having gotten down to 253 pounds before surgery. Unfortunately, in the wake of her father's death in 2011, she regained 100 pounds. She enlisted Dr. Now's help once again to get down to 200 pounds, but she tragically died in October 2021 due to sepsis from an infection.

11 Sean Milliken (My 600-Lb Life Season 4)

Sean Milliken was one of the heaviest ever cast on My 600-lb Life when he debuted in 2016. At the time, he weighed over 900 pounds and had sought out Dr. Now because he knew he wouldn't live very long in his current state; he even struggled to stand for more than 30 seconds. Sean's weight-gaining journey started after he suffered a leg injury in high school and was confined to a bed.

At that time, the My 600-lb Life star also had a strained relationship with his father, culminating in his overindulgence in food. However, Sean's mother shockingly passed away a year after his appearance in My 600-lb Life. Still, Sean successfully lost about 400 pounds following Dr. Now's guidance. Sadly, Sean passed away in February 2019 at 29 years old due to complications from an infection, as reported by his father.

10 Robert Buchel (My 600-Lb Life Season 4)

When Robert Buchel debuted on My 600-lb Life, he weighed about 842 pounds. He sought Dr. Now's help to lose weight in preparation for his upcoming wedding. Robert showed tremendous progress during his first month in the program, shedding about 124 pounds before losing another 98 pounds at a rehab center.

My 600-lb Life's Robert then lost another 78 pounds before surgery to remove a lymphedema mass that hindered his weight loss. Sadly, after the surgery, Robert developed an addiction to pain medication. The obsession was so intense he reportedly tore some of his surgical stitches to get more painkillers. Sadly, he suffered a heart attack and died on November 15, 2017, at the age of 41, becoming the first person to pass away while filming his episode on My 600-lb Life.

9 James King (My 600-Lb Life Season 5)

When James King debuted on My 600-lb Life season 5, he weighed 791 pounds. James, who was also a father of six, was one of the heaviest cast members in the history of the series at that point. According to The List, his condition was so dire Dr. Now once had to call Adult Protective Services to investigate if James' wife was illegally feeding her husband while he attempted to lose weight.

Still, a year later, during James' appearance on the spin-off My 600-lb Life: Where Are They Now? James' weight had increased to 840 pounds. Afterward, James was released from Dr. Now's program. Surprisingly, James lost about 400 pounds over the following years until he died in 2020 due to kidney failure at 49. James was survived by his wife, six children, and 19 grandchildren (via People).

8 James "LB" Bonner (My 600-Lb Life Season 6)

Similar to other My 600-lb Life cast members, James Bonner's overeating problem started when he was a child after losing a beloved aunt. James was dealing with an addiction to both food and alcohol, which brought his weight to 600 pounds when he sought Dr. Now's help. He had also lost a foot in a car accident and could not care for himself. James' stint with Dr. Now was very successful; he lost about 316 pounds and continued living healthy after the show, which resulted in additional weight loss.

During this time, he also amassed a substantial following on social media, where he detailed his weight loss journey. However, in a bizarre social media post in 2018, James noted in a Facebook post via TMZ, "I just want to thank everyone who has shown me love and support throughout my journey... I've realized a few things over the last few days, and it's time that I face my demons head-on." Days later, James' body was found in a car park in his hometown of Lexington, South Carolina, with a gunshot wound to the head. The local police would later rule the cause of death as suicide.

7 Lisa Fleming (My 600-Lb Life Season 6)

Lisa Fleming debuted on My 600-lb Life season 6, and her weight-gaining story was emotionally packed. According to Lisa, her unhealthy relationship with eating started as a child when she turned to food to help deal with her parent's divorce. Her situation became worse when her mother started using eating to punish her.

Lisa's mother once forced her to eat an entire cake as punishment for tasting it without permission. Still, it was after Lisa found maggots in the folds of her skin that she sought out Dr. Now. Despite being confined to bed, Lisa lost about 200 pounds after her time on the series. Sadly, she passed away in 2018 due to her poor health at the age of 50.

6 Renee Biran (My 600-Lb Life Season 6)

Renee Biran was a beloved My 600-lb Life season 6 cast member. She's best known for her fetish modeling career for customers who paid to watch her eat. Renee was diagnosed with Guillan-Barre Syndrome in 2019 and allegedly passed away from complications from the illness in 2021. She was 56 years old.

5 Destinee LaShaee (My 600-Lb Life Season 7)

Destinee LaShaee was the first transgender on My 600-lb Life when she debuted during season 7. She weighed close to 700 pounds then but quickly got to work. During her time in the series, Destinee lost over 500 pounds and was a role model for people looking to lose weight. The My 600-lb Life star was vocal about mental health struggles and openly discussed her battle with depression. Sadly, she passed away on February 8, 2022, according to her brother Wayne Compton who announced the news on Facebook (via People). She was only 30 years old when she died, and her cause of death is unknown.

4 Kelly Mason (My 600-Lb Life Season 7)

When fans first met Kelly Mason in My 600-lb Life, she weighed about 700 pounds. She also suffered from high blood pressure, arthritis, thyroid issues, diabetes, and a pulmonary embolism. All those health issues challenged her survival, but Kelly bravely embraced them and worked hard. She eventually dropped about 100 pounds and another 220 while awaiting surgery. But Kelly would sadly not live up to that moment, as she died of a cardiac arrest in her sleep at the age of 41.

3 Coliesa McMillian (My 600-Lb Life Season 8)

Coliesa McMillian made her debut during My 600-lb Life season 8, weighing in at 643 pounds and dealing with various health issues. She had also suffered a heart attack at 39. However, after joining Dr. Now's program, she dropped about 150 pounds. Although the weight loss was insufficient for surgery, Dr. Now conducted the surgery due to Coliesa's life-threatening intestinal blockage.

However, Coliesa started experiencing complications after the procedure, and her niece reported that her gastric sleeve popped, which caused sepsis. As a result, Coliesa used a ventilator for two and a half weeks before being put in a medically induced coma and then on life support. Sadly, Coliesa died in September 2020 at the age of 41.

2 Gina Krasley (My 600-Lb Life Season 8)

Gina Krasley first appeared on My 600-Lb Life season 8 alongside her wife, Beth. While she was able to lose 170 pounds by March 2021. While she eventually lost over 300 pounds after the show, Gina's health continued to deteriorate. She passed away on August 1, 2021, due to health complications at the age of 30. The exact cause of death is unknown.

1 Larry Myers Jr. (My 600-Lb Life Season 10)

Larry Myers appeared as an aspiring gospel musician on My 600-lb Life season 10. Mr. Buttermilk Biscuits, as he was known on the show, weighed 940 pounds when he began his weight loss journey. Unfortunately, Larry died of a heart attack at home in Houston, Texas, in January 2022. He was 49 years old

Sources: The List, People, TMZ, People